"A lot of people are saying this is going to be the death of Twitter, and I don't understand that at all," Cherwenka added. "It's just another stage in Twitter's acceleration."
"The challenge for Twitter -- besides, of course, getting a business model in place to handle the infrastructure required to sustain this kind of growth -- is going to be maintaining the fact that it's the community at large, not the celebrity users, that's at the core of this service," said Caroline McCarthy, who writes a CNET News blog about social media.
"The power of Twitter is about the millions of people using it and how easily it is to filter and aggregate their thoughts and conversations," McCarthy told CNN. "It can't be all about Ashton and Oprah."
In the much-publicized duel, Kutcher's Twitter account crossed the 1 million mark on Twitter about 2:13 a.m. ET Friday, narrowly beating CNN's breaking-news feed, which had 998,239 followers at the time. CNN passed the mark at 2:42 a.m. ET.
On Friday, Kutcher went on "Larry King Live" to talk about the battle and why he felt the duel was so important.
"We now live in an age in media that a single voice can have as much power and relevance on the Web, that is, as an entire media network," he said. "And I think that to me was shocking."
Early Friday Winfrey sent her first tweet from the Chicago, Illinois, set of her TV show. The all-caps message was sent at 10:10 a.m. ET and said, "HI TWITTERS. THANK YOU FOR A WARM WELCOME. FEELING REALLY 21st CENTURY."
Winfrey drew more than 73,000 Twitter followers before she sent out her first tweet. By Friday afternoon her Twitter following had climbed above 100,000.